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September 28th marks National Penicillin Allergy Day, the 93rd anniversary of the discovery of penicillin by Alexander Fleming who was Scottish physician-scientist. Penicillin is instrumental in modern medicine in its ability to combat infections and remains the most efficacious and safe treatment for many life-threatening infections.
Approximately, 10 % of the United States populations report to be allergic to penicillin, Avoiding Penicillin will lead to overuse of broad-spectrum antibiotics and build resistance to more serious bacteria, recent studies show that 90% of the people who have reported penicillin allergies can take penicillin again, as some people are either mislabeled or misdiagnosed with penicillin allergies.
Evaluating a person with a history of penicillin reactions will determine either the person is at low or high risk for future use of penicillin. This risk can be determined based on the clinical history, type of reactions experienced in the past, frequency of past reactions, and the duration of avoidance.
To evaluate future risk of penicillin use, a skin test can be performed; if it is negative there is a 95% chance that a person can tolerate penicillin well and performing a challenge dose of Amoxicillin after a negative skin test will lead to nearly 100% tolerance of future penicillin use.
Cephalosporins are a group of antibiotics related to penicillin. About 2% of people who are allergic to penicillin will react to Cephalosporins.
If you have a history of penicillin reactions and are interested in having a proper diagnosis, call our office to schedule consultation with Dr. Khoudary.
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